Association between an isothiocyanate and Levodopa in the treatment of Parkinson's disease

The invention consists in the association between the element Sulforafane (SUL), extracted from plants such as cauliflower and similar, with the drug Levodopa, moreover it consists in the evaluation of neuroprotective effect against L-Dopa neurotoxicity. It was assessed that this association showed ...

Isothiocyanates, Glucosinolates, Levodopa, Parkinson's disease, Neuroprotection, Combined therapy

Method for production of functional plant, energizing, anti-depressive and euphoric sparkling beverages

The method for production of functional plant, energizing, anti-depressive and euphoric sparkling beverages is according our own ‘know how” and Bulgarian patent for invention № 66092/2011 with priority V.2008г. and is based on the usage of N2O gas and optimized parameters for its absorption in a ga...

Pharmaceutical preparations for transdermal use

This invention concerns a new pharmaceutical combination which can be used for the treatment of muscular pain and acute backache. It consists of a topical vehicle containing a combination of a non-steroid anti-inflammatory drug (NSAID) and a commonly used therapeutical substance that can act synergi...

Anti-inflammatory, analgesic activity, emulgel, topic administration

Artificial metalloenzyme for gene correction

The goal of our research is to design and prepare a new artificial, DNA sequence-specific metalloendonuclease, being safe in a term that it should not exert any cytotoxicity arising from cleavage at off-target sites. Such nuclease is being designed by the introduction of a control mechanism of actio...

artificial metallonuclease, gene correction, genetic disease

Nanotechnology for controlled drug release: Core-shell nanoparticles for sustained release of drug molecules

The invention is a novel method of core-shell nanoparticle preparation of protein drugs or protein-bound active compounds, which provides a way of the formulation of sustained release products. Benefits of our novel method of core-shell nanoparticle preparation of protein drugs or protein-bound acti...

Protein precipitation, chitosan, core-shell nanoparticle, layer-by-layer self-assembly, polyelectrolyte multilayers, drug release kinetics, sustained release, interferon-α

A Knowledge Base structure for Adverse Drug Event prevention

In the context of the PSIP (Patient Safety through Intelligent Procedures in medication - http://www.psip-project.eu/) EU project, a knowledge-based approach has been designed and developed for the construction of a framework suitable for the management and effective use of knowledge related to ADE ...

Adverse Drug Event Signals, Knowledge Engineering, Knowledge Model, Knowledge Base

Clinical Decision Support System for Adverse Drug Event prevention

In the context of the PSIP (Patient Safety through Intelligent Procedures in medication - http://www.psip-project.eu/) EU project, a generic, knowledge-based, Clinical Decision Support System has been designed and developed for the management and effective use of knowledge related to ADE prevention....

Adverse Drug Event prevention, Clinical Decision Support System, Medication Safety

New Compounds modulating the Gpr17 Receptor

Selective and specific GPR17 ligands are still not known and the drugs used to date to modulate its activity could easily cross-react with other G protein coupled receptors, causing undesirable side effects. The protected molecules are completely new and this could be an interesting aspect for all w...

GPR13, stroke, Multiple sclerosis, Alzheimer’s, Parkinson’s, Huntington’s, Chorea

MeSHy, a Web-based Biotext Mining Tool for Unanticipated Knowledge Discovery

MeSHy was developed implementing a mainly statistical algorithm. The algorithm searches PubMed for documents relevant to a user’s query and ranks the pairs of their MeSH terms promoting unusual occurrences. The first in rank MeSH term pairs (and therefore the corresponding documents) more often than...

Knowledge Discovery, Statistical Algorithm, Text Mining, Biomedical Texts, PubMed

Development and Characterisation of Nanomaterials (e.g. thin films, nanoparticles and nanofibres) for applications in Regenerative Medicine and Drug Delivery

LTFN is active at least a decade on the advanced deposition techniques of thin films and state-of-the art non-destructive nano-precision characterisation techniques with special emphasis on the topographical, surface energy, optical, electrical and nanomechanical properties of thin films. The soluti...

Nanofibres, Nanoparticles, Thin Films(Nanomaterials), Compatibility, Adsorption, Proteins, Cells, Toxicity